MK-677 Ibutamoren

What it is, how it works and what are the benefits.

What is MK-677 (Ibutamoren)?

MK-677 is an selective agonist of the gherlin receptor and a growth hormone secretagogue stimulating the growth hormone. It is currently under development as a potential treatment of reduced level of growth hormones (Growth hormone deficiency) and frailty in elderly. It has many different names like MK-0677, L163,191, MK-677 and Ibutamoren. Human studies has shown to sustain activation of GH-IGF-1, increase in lean body mass and bone mineral density.

It has been demonstrated to increase the release of, and produces sustained increases of several hormones including GH and insulin-like growth factor 1 (IGF-1)

How does Ibutamoren work?

Ibutamoren promotes the secretion of the growth hormone(GH) and increases insulin like growth factor 1(IGF1). It can increase the growth hormone by selective mimicking the hormone: Ghrelin. And binding to one of the ghreling receptors GHSR in the brain. When GHSR is activated it releases spikes of growth hormone.

GHSR controls your appetite, biological rhythms, pleasure and mood. That’s why many people experience a lot of hunger when using MK-677.

Ibutamoren is so great because it increases growth hormone levels but doesn’t increase in other hormones such as cortisol.

MK-677 Molecule structure

Mk-677 Protocols

Studies has shown create results with 0,2mg/kg and up to 0,8mg/kg that would be in a range of 15mg to 80mg per day of MK-677. This was done on children with GH deficiency. The only took it for 7 days.

The longer you take Ibutamoren the more benefits you get. A populair dose of MK-677 would be 10-30mg a day. Studies have shown a 80 increase in IGF-1 with 25mg a day.

Some people take 10mg before bed and 10mg on waking up. But you can experience lethargy when taking it when you wake up.

Side effects and benefits of MK-677


  • Increased quality of Sleep(REM quality) and sleep duration;
  • Improved quality of Skin, Hair and Nails;
  • Increase in lean body mass and bone density;
  • Orally taken;
  • Transiently increase metabolic rate which results in losing body fat;
  • By increasing IGF-1 it can improve memory and learning;
  • Faster healing of wounds and Tissue Regeneration.

Side Effects:

  • Increase in appetite;
  • Increase in fasting blood glucose;
  • Decrease in insulin sensitivity;
  • Water retention.

MK-677 Can make you lose body fat