LGD-4033 (Ligandrol)

What is LGD-4033?

LGD is a selective androgen receptor modulator(SARM), developed for the treatment of muscle wasting diseases and Osteoporosis. LGD -4033, also called Ligandrol or VK5211, was discovered a company called Ligand Pharmaceuticals and is currently still under development.

“Prior results from studies evaluating VK5211 in animals and humans have demonstrated promising anabolic effects on bone and muscle mass”

LGD-4033 is expected to produce the benefits of testosterone with improved safety, tolerability and acceptance due to tissue-selective mechanisms of action and oral routes administration.

In a study done with 76 healthy men(21-50 years) LGD was well tolerated and lean body mass increased on dose-dependently up to 1.5kg in 3 weeks. Hormone levels and lipids returned to baseline after treatment discontinuation. The conclusion of this study was that LGD is safe, had a favorable pharmacokinetic profile and increased lean body mass during this 3 weeks period without change in the prostate-specific antigen.

LGD-4033 Study results

What are the benefits and side effects of LGD-4033?

The biggest benefit of LGD-4033 is the increase in Lean Body Mass, Muscle Strength, and performance. The studies show that there are almost no side effects while using LGD.


  • Improvement of Lean Body Mass(LBM)
  • Improvement of Muscle Strength hand Physical performance
  • Improvement of Bone Strength
  • Enhance Quality of life (QOL)
  • Hormone levels go back to baseline after usage

Side effects:

  • Suppression of natural testosterone production (dose dependent)
  • Water retention

How does LGD-4033 work?

LGD-4033 is a selective androgen receptor modulator or in other words SARM. They are intended to have the same effect as anabolic steroids but with fewer side-effects, because there are much more selective in their action, allowing them to be used for many more clinical indications.

SARMs can be orally taken and became design molecules that selectively target the androgen receptor, which means that it can target the receptors way more effective than normal testosterone.

Safety and Tolerability of LGD-4033

Safety and Tolerability of LGD-4033

How to use LGD?

LGD comes in powder or liquid form and is taken orally. Normal doses can vary from 1mg to 10mg a day for 6-12 weeks. You can choose to up the dose slowly from 5mg for 4 weeks then 10mg for 6 weeks. Or you can just take 10mg a day for 10 weeks straight. There is not much research done on the long-term dosage of LGD. Anecdotally, a lot of people say that 10mg a day is the sweet spot for lean body mass and almost no side effects.

research chemicals

LGD-4033 experiences

Because Ligandrol is still a research chemical at this moment there are only anecdotal experiences. Lots of people say that LGD-4033 gives them a great boost in overall muscle mass, some people even say to gained 15lbs in 10 weeks with 10mg a day. A lot of people say that they experience water retention so a lot of weight gained is water, but also lean body mass.

People say that 10mg a day is the limit and should not be exceeded. Anecdotally people gained a lot of weight but also gained a lot of strength with their lifts. Some people gained 40lbs on their bench in a couple of weeks. LGD-4033 gives some people a lot of size in their delts and trapezius, even more than normal anabolic steroids!

All in all, are people very pleased with their results and think that LGD is a good way to gain lean body mass and overall strength in the gym

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[Editor’s Note: LGD-4033, what it is, how it works and what are the benefits is intended as a collaborative, growing body of work, as opposed to a static, singleauthor piece. If you have comments, suggestions and of course any corrections, please contact us via email: info @ sarms4you (nospaces).]